Protective immunity against malaria after vaccination

Protective immunity against malaria liver stage after vaccination with live parasites.

Despite nearly 100 years of research and control efforts, malaria remains one of the most important infectious diseases. An efficient vaccine would be a powerful to tool to reduce mortality and morbidity. Experimentally, induction of sterile immunity in humans after vaccination with attenuated sporozoites has been obtained. This observation has spurred the search for subunit vaccines that aim t...

Protective Immunity and Vaccination Against Cutaneous Leishmaniasis

Although a great deal of knowledge has been gained from studies on the immunobiology of leishmaniasis, there is still no universally acceptable, safe, and effective vaccine against the disease. This strongly suggests that we still do not completely understand the factors that control and/or regulate the development and sustenance of anti-Leishmania immunity, particularly those associated with s...

Cripto-1 vaccination elicits protective immunity against metastatic melanoma

Metastatic melanoma is a fatal disease that responds poorly to classical treatments but can be targeted by T cell-based immunotherapy. Cancer vaccines have the potential to generate long-lasting cytotoxic CD8(+) T cell responses able to eradicate established and disseminated tumors. Vaccination against antigens expressed by tumor cells with enhanced metastatic potential represents a highly attr...

Against Liver-Stage Malaria The Complexity of Protective Immunity

Protective immunity against Plasmodium berghei malaria after administration of interleukin-12.

Interleukin-12 (IL-12) has been shown to induce protection in mice against Plasmodium cyanomolgi and in rhesus monkey against Plasmodium yeolii. This study is to investigate whether recombinant IL-12 can induce protection in BALB/c mice against Plasmodium berghei. Five mice were given intraperitoneal injection of 7.5 micrograms/kg body weight recombinant mouse IL-12 two days prior to challenge ...